Methandienone (Dianabol) is a drug belonging to a number of left-sided anabolic steroids, widely known as a doping used in sports medicine to increase muscle mass. The drug enhances anabolic and suppresses catabolic processes caused by glucocorticosteroids, promotes an increase in muscle mass, forms a positive nitrogen balance, accelerates the breakdown of subcutaneous fat, suppresses the immune response due to an increase in the synthesis of an inhibitor to complement C-1 fraction and a decrease in the level of C-2 C-4 fractions complement, with regular use, activates the development of secondary sexual characteristics according to the male type.
Methandienone was originally developed by CIBA (now the multinational pharmaceutical corporation Novartis) in 1955 and was sold in Germany and the United States.
As CIBA’s Dianabol product, methandienone quickly became the first widely used anabolic agent among professional and recreational athletes and remains the most commonly used orally active anabolic agent for non-medical use.
It first appeared on sale in 1958 in the United States in the form of 5 mg tablets under the trade name Dianabol. It is the first drug in its class and has a long history of use in sports medicine as a doping. It should be noted that until the end of the 1960s, the drug was not considered doping, only stimulants such as amphetamine, cocaine, ephedrine and their analogues were prohibited for athletes.
It has pronounced anabolic and moderate androgenic properties. It is used in the treatment of burns, fractures, kidney failure, as well as to compensate for protein metabolism, including in sports medicine (for muscle building). Due to the presence of a 17-alkyl group, it has hepatotoxicity; with prolonged and significant overdose, it can cause obstructive jaundice caused by hyperproduction of bile and stretching of the biliary tract. This condition may be accompanied by pain and dyspeptic disorders. Treatment is symptomatic, aimed at improving the bile outflow. Contraindicated in liver disease.
The substance is currently controlled in the United States and the United Kingdom and remains popular among bodybuilders. Methandienone is readily available over the counter in some countries such as Mexico and is also produced in some countries in Asia.
Penetrating into the cell nucleus, it activates the genetic apparatus of the cell, which leads to an increase in the synthesis of DNA, RNA and structural proteins, the activation of tissue respiration chain enzymes and an increase in tissue respiration, oxidative phosphorylation, ATP synthesis and the accumulation of macroergs inside the cell.
Stimulates anabolic and suppresses catabolic processes caused by GCS.
It leads to an increase in muscle mass, a decrease in fat deposits and a negative nitrogen balance. Hematopoietic action is associated with an increase in the synthesis of erythropoietin.
The antiallergic effect of Methandienone is due to an increase in the concentration of the C-1 inhibitor of the complement fraction and a decrease in the content of C-2 and C-4 complement fractions. The presence of androgenic activity may contribute to the development of male secondary sexual characteristics. The duration of action of Methandienone is up to 14 hours.
Chemical structure of Dianabol
In its chemical structure, Dianabol is similar to 17-alpha-methyltestosterone, as a result of which Dianabol has a strong anabolic and androgenic effect. Which manifests itself in a significant increase in strength and muscle mass. Also, the structure of the molecule of this drug determines its side effects. Due to its similarity to testosterone, it aromatizes very easily. This substance also has a strong androgenic effect. Therefore, estrogenic and androgenic side effects are not uncommon when using Danabol.